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BioCore HIC-OH Columns

BioCore HIC is a family of high-performance, hydrophobic interaction chromatography columns that separate monoclonal antibodies (mAbs), bispecific antibodies (BsAbs) and antibody-drug conjugates (ADCs) based on their difference in surface hydrophobicity.
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BioCore HIC is a family of high-performance, hydrophobic interaction chromatography columns that separate monoclonal antibodies (mAbs), bispecific antibodies (BsAbs) and antibody-drug conjugates (ADCs) based on their difference in surface hydrophobicity.

Main Features

  • Optimal selectivity for fusion protein and BsAb

  • Minimal undesired interactions for low carryover

  • Excellent mechanical strength for column robustness

  • Good column-to-column consistency

Specifications

Product Name

BioCore HIC-OH

Functional Group

Hydroxyl

Substrate

Monodispersed, wide-pore silica particles

Particle Size

3 & 5 µm

Pore Size

1000 Å

Pressure Limit

6000 psi

Temperature Limit

60 

pH Range

2-8

Application

Oxidation variants in fusion proteins, impurities in BsAb

Applications

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Product Name

Particle Size

(µm)

Length

(mm)

ID (mm)

4.6

BioCore HIC-OH

5

250

B753-050100-04625S

150

B753-050100-04610S

50

B753-050100-04605S

3

100

B753-030100-04610S

50

B753-030100-04605S